Endocrine Abstracts

Serum TSH is the most sensitive index of thyroid function in the absence of hypothalamic–pituitary disease.However, TSH reference limits are controversial, particularly the upper limit. District and age subpopulations have unique TSH distribution. We investigated characterization of thyroid hormones in Japanese elderly. 859 participants (mean age 74.3 years) over 60 years without known thyroid disease were surveyed.Percentages...

Background: Although primary aldosteronism (PA) is the common cause of hypertension subjected to surgery, methods of pathological confirmation of aldosterone overproduction have not been established. Aim of the study was to investigate immunohistochemically the expression of CYP11B2 in the adrenal tissue of PA.Methods: Twenty five patients with PA including 20 patients with aldosterone-producing adenoma (APA) and 5 patients without APA (non-APA) were stu...

Multiple endocrine neoplasia type2 (MEN 2) (OMIM 171400) is an autosomal dominant inherited cancer syndrome caused by activating mutations in the RET proto-oncogene. MEN 2 is classified into three subtypes: MEN 2A, MEN 2B and familial medullary thyroid carcinoma(FMTC). MEN 2B accounts for 5–10% of MEN2 cases. More than 95% of MEN 2B patients carry M918T mutation of RET, and 2–3% harbor A883F mutation. There has been three reports of cases with MEN 2B phenotype caused...

Primary aldosteronism (PA) is the most common cause of secondary hypertension. Although decline in renal function especially that experienced after adrenalectomy (ADX) has been demonstrated, details of the mechanism remain to be elucidated. Aim of the study was to investigate the factors predicting renal outcome after ADX in PA. Twenty patients with PA and four patients with non-functioning adrenal tumor (NFT) as control were studied. eGFR, serum potassium, plasma aldosterone ...

Type 1 iodothyronine deiodinase (D1), a selenoenzyme that catalyzes the bioactivation of thyroid hormone, is expressed mainly in the liver. Its expression and activity are modulated by several factors, but the precise mechanism of its transcriptional regulation remains unclear. In the present study, we have analyzed the promoter of human D1 (hDIO1) gene to identify factors that prevalently increase D1 activity in the human liver. Deletion and mutation analyses demonstrated tha...

Inflammatory lesions of the pituitary gland are rarely encountered. Recently, the concept of IgG4-related systemic disease was proposed and several cases associated with infundibulo-hypophysitis were reported. We report 4 additional cases and review the cases in the literature. Case 1: 75-year-old female had diabetes insipidus due to infundibulo-neurohypophysitis for 25 years and chronic thyroiditis. She developed obstructive jaundice and surgery showed autoimmune pancreatitis...